Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Comparative pathology in risk assessment]

M Rosenbruch1

  • 1Antrittsvorlesung an der Medizinischen Fakultät der Heinrich-Heine-Universität Düsseldorf.

Zentralblatt Fur Pathologie
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The early chick embryo as a model to evaluate cardiovascular effects of adrenaline and nicotine.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

The chick embryo yolk-sac blood vessel system as an experimental model for irritation and inflammation.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

[Species-specific comparison of upper airways].

Pneumologie (Stuttgart, Germany)·2010
Same author

Pleistophora infestation in fathead minnows, Pimephales promelas (Rafinesque).

Journal of fish diseases·2005
Same author

[Broncho-alveolar lavage in humans and animals -- comparative aspects].

Pneumologie (Stuttgart, Germany)·2005
Same author

Pathology and treatment of Eimeria zuernii coccidiosis in calves: investigations in an infection model.

Parasitology international·2005
Same journal

[Simultaneous occurrence of medullary and papillary carcinoma in the same thyroid lobe].

Zentralblatt fur Pathologie·1995
Same journal

[Xanthoid corpuscles in the cytoplasm of rat kidney tubule epithelium].

Zentralblatt fur Pathologie·1995
Same journal

Brain stem gliosis in the victims of sudden infant death syndrome (SIDS): a sign of retarded maturation?

Zentralblatt fur Pathologie·1995
Same journal

Sinusoidal changes in extratumoral liver tissue. Report of a case of metastatic liver small cell carcinoma with collagen IV detection and ultrastructural studies.

Zentralblatt fur Pathologie·1995
Same journal

The fine structure of normal and ectopic (tubal) human placental villi as revealed by scanning and transmission electron microscopy.

Zentralblatt fur Pathologie·1995
Same journal

Ultrastructure of composite tumours consisting of giant cell fibroblastoma and dermatofibrosarcoma protuberans.

Zentralblatt fur Pathologie·1995
See all related articles

This study explores comparative pathological research in drug development, focusing on animal models to assess drug safety and efficacy for human risk assessment. It highlights the importance of extrapolating animal data to humans while considering ethical implications.

Area of Science:

  • Pathology
  • Toxicology
  • Drug Research

Context:

  • Comparative pathological studies are crucial in drug research.
  • Disease models and indicator systems are used to evaluate test substances.
  • Risk assessment considers human exposure in environmental, occupational, and patient settings.

Purpose:

  • To assess the effectiveness and tolerance of test substances.
  • To evaluate study results using qualitative morphological and quantitative morphometric methods.
  • To extrapolate findings from animal models to human health.

Summary:

  • The research involves comparative pathological studies using disease models.
  • Evaluation employs both qualitative morphological and quantitative morphometric techniques.

Related Experiment Videos

  • A key challenge is extrapolating animal experimental results to human risk assessment.

    • Impact:

    • Provides a framework for evaluating drug effectiveness and safety.
    • Informs risk assessment strategies for human exposure to substances.
    • Addresses the ethical considerations and challenges of animal experimentation in research.