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[Alpha-fetoprotein serum level in healthy persons]
Vutreshni Bolesti
|January 1, 1978
Summary
This study determined normal serum levels of alpha-fetoprotein (AFP) in healthy Bulgarians using radioimmunoassay. Mean AFP levels were 5.16 ng/ml, with values over 15 ng/ml considered elevated.
Area of Science:
- Clinical chemistry
- Immunology
- Biomarker research
Context:
- Establishing reference ranges for serum biomarkers is crucial for accurate clinical diagnosis.
- Alpha-fetoprotein (AFP) is a protein produced during fetal development, with elevated levels in adults potentially indicating certain health conditions.
- Limited data exists on AFP reference ranges specifically within the Bulgarian population.
Purpose:
- To establish reference ranges for serum alpha-fetoprotein (AFP) levels in a healthy Bulgarian cohort.
- To define normal, upper limit, and elevated thresholds for AFP in this population.
- To provide a baseline for future clinical and research applications in Bulgaria.
Summary:
- Serum AFP levels were measured in 75 healthy Bulgarian subjects (aged 12-80 years) via radioimmunoassay.
- The mean serum AFP level was found to be 5.16 ng/ml.
- The upper limit of normal was set at 12 ng/ml, with levels exceeding 15 ng/ml considered positively elevated.
Impact:
- Provides essential reference values for serum AFP in the Bulgarian population.
- Aids clinicians in the accurate interpretation of AFP test results for disease screening and monitoring.
- Contributes to the broader understanding of biomarker variability across different ethnic groups.