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Related Experiment Videos

Baclofen therapy for chronic hiccup

C Guelaud1, T Similowski, J L Bizec

  • 1Service de Pneumologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

The European Respiratory Journal
|February 1, 1995
PubMed
Summary

Baclofen effectively treats chronic hiccups, resolving or reducing symptoms in most patients. This suggests baclofen is a key treatment for chronic hiccups, whether idiopathic or linked to gastro-esophageal issues.

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Area of Science:

  • Gastroenterology
  • Neurology

Background:

  • Chronic hiccups, lasting over 7 days, are rare but severe, potentially indicating underlying diseases or being idiopathic.
  • Numerous treatments exist, often reported as case studies, with baclofen emerging as a potential therapy.

Purpose of the Study:

  • To evaluate the therapeutic efficacy of baclofen in a large series of patients suffering from chronic hiccups.
  • To determine baclofen's position in treating chronic hiccups, considering gastro-esophageal abnormalities.

Main Methods:

  • Systematic investigation of the upper gastro-esophageal tract (fibroscopy, manometry, pH monitoring) was performed in patients with chronic hiccups.
  • Baclofen was administered to 37 patients with chronic hiccups (average duration 4.6 years), either as a first-line treatment or after other treatments failed.

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Main Results:

  • Baclofen achieved long-term complete resolution in 18 patients and considerable decrease in 10 others, with 28 out of 37 patients experiencing significant relief.
  • No significant difference in baclofen's efficacy was observed between patients with and without gastro-esophageal disease.

Conclusions:

  • So-called idiopathic chronic hiccups frequently stem from underlying gastro-esophageal abnormalities.
  • Baclofen shows encouraging results and may be a major treatment option for chronic hiccups, including idiopathic cases or those refractory to gastro-esophageal disease treatment.