[Validity of the neuroethological model of obsessive-compulsive disorder]

In the aetiology and pathogenesis of obsessive-compulsive disorders (OCD) multiple factors play a role. Among biographic, genetic and behavioral factors, biological mechanisms seem to be of relevance. Some authors have proposed a neuroethiological model. This model implies a disconnection in neural circuits, linking prefrontal cortex, basal ganglia and thalamus. This review article addressed the question as to whether brain imaging studies support this theory. Conclusions drawn from these studies must be viewed cautiously because findings are not consistent and because of methodological limitations. The validity of a neuroethiological model in OCD seems questionable.