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Related Experiment Videos

Antibiotic resistance in group A streptococci

M A Gerber1

  • 1Department of Pediatrics, University of Connecticut Health Center, Farmington, USA.

Pediatric Clinics of North America
|June 1, 1995
PubMed
Summary

Erythromycin resistance in Group A Streptococcus (GAS) is a concern in some countries but not the US. Penicillin remains effective, while tetracyclines and sulfonamides are not recommended for GAS infections.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Group A Streptococcus (GAS) infections remain a significant public health concern.
  • Antimicrobial resistance patterns influence treatment strategies for GAS infections.

Purpose of the Study:

  • To assess the current antimicrobial susceptibility of Group A Streptococcus (GABHS).
  • To evaluate the appropriateness of various antibiotics for treating GABHS infections.

Main Methods:

  • Review of existing literature on GABHS antimicrobial resistance.
  • Analysis of susceptibility data for penicillin, macrolides, tetracyclines, sulfonamides, cephalosporins, and clindamycin.

Main Results:

  • Penicillin remains highly effective against GABHS, with no significant changes in susceptibility observed.
  • Erythromycin resistance is a problem in some regions but not the US; newer macrolides show similar susceptibility patterns.
  • Tetracyclines are inappropriate due to high resistance rates; sulfonamides are ineffective for upper respiratory tract eradication.
  • Clindamycin resistance is unusual and it serves as an alternative for macrolide-resistant strains.

Conclusions:

  • Penicillin is the preferred antibiotic for GABHS infections.
  • Periodic monitoring of erythromycin resistance in GABHS is reasonable.
  • Alternative antibiotics like clindamycin are valuable for specific patient populations with resistant strains.

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