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Related Experiment Videos

Vancomycin resistance in the enterococcus. Relevance in pediatrics

L B Rice1, D M Shlaes

  • 1Infectious Diseases Section, Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.

Pediatric Clinics of North America
|June 1, 1995
PubMed
Summary

Enterococci are becoming resistant to many antibiotics, posing a threat of untreatable infections in children. This highlights the need for new antimicrobial agents and vigilant surveillance of resistant strains.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Enterococci are significant nosocomial pathogens.
  • They possess intrinsic resistance to many antimicrobial agents.
  • Antimicrobial use, like cephalosporins, is linked to increased enterococci isolation in pediatric settings.

Purpose of the Study:

  • To highlight the growing threat of multidrug-resistant enterococci.
  • To emphasize the need for surveillance and new antimicrobial development.

Main Methods:

  • This study is a review of current literature on enterococcal resistance.
  • It analyzes trends in antimicrobial resistance and clinical implications.

Main Results:

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  • Enterococci exhibit both intrinsic and acquired resistance to antibiotics.
  • Multidrug-resistant strains are increasingly isolated from infected children.
  • There is a risk of vancomycin resistance spreading to other pathogens.

    • Conclusions:

    • Vigilant surveillance for resistant enterococci is crucial.
    • Infection control measures like isolation are necessary.
    • Research into resistance mechanisms and new antimicrobial agents is urgently needed.