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Cervical chemonucleolysis

F B Gomez-Castresana1, C Vazquez Herrero, J L Baltes Horche

  • 1Clinica Santa Elena, Madrid, Spain.

Orthopedics
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Chymopapain chemonucleolysis effectively treated cervical disc herniations in 85% of patients. This minimally invasive procedure showed high efficacy and safety, with no complications reported in the study.

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Area of Science:

  • Neurosurgery
  • Minimally Invasive Procedures
  • Biologics

Background:

  • Cervical disc herniations present a significant challenge in spinal surgery.
  • Conservative treatments often yield suboptimal outcomes for soft cervical disc herniations.
  • Chemonucleolysis offers a less invasive alternative to surgical discectomy.

Purpose of the Study:

  • To evaluate the efficacy and safety of chymopapain chemonucleolysis for soft cervical disc herniations.
  • To assess the outcomes and complication rates associated with this minimally invasive treatment.
  • To determine the rate of herniation resolution post-chymopapain injection.

Main Methods:

  • Forty patients with 44 cervical disc herniations underwent chymopapain injection (1500-1800 U) between 1988 and 1992.

Related Experiment Videos

  • Procedures were performed under neuroleptanalgesia with prophylactic H1-H2 receptor antagonists.
  • Anterolateral needle insertion guided by X-ray; diagnosis confirmed by imaging (CT, MRI, etc.) and discography.

    • Main Results:

    • Overall satisfactory results were achieved in 85% (34/40) of patients.
    • Fair results were observed in 7.5% (3/40), and poor results in 7.5% (3/40).
    • Post-injection MRI in 18 patients showed complete herniation disappearance in 13 (72%).

    Conclusions:

    • Chymopapain chemonucleolysis is an effective and safe treatment for soft cervical disc herniations.
    • The procedure demonstrated a high success rate with no reported complications.
    • Minimally invasive chymopapain injection offers a viable therapeutic option for cervical disc disease.