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Fibroblasts as efficient antigen-presenting cells in lymphoid organs
T M Kündig1, M F Bachmann, C DiPaolo
1Institute of Experimental Immunology, University of Zürich, Switzerland.
Science (New York, N.Y.)
|June 2, 1995
Abstract:
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.