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Recent advances in phage display

¹Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037.

Current Opinion in Biotechnology

|October 1, 1993

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Phage display technology enables the selection of peptides and proteins for biotechnology applications. This method facilitates the isolation of therapeutic antibodies and the evolution of novel enzymes.

Area of Science:

Biotechnology
Molecular Biology
Protein Engineering

Background:

Filamentous phage display is a powerful technique for selecting peptides and proteins.
This technology has advanced rapidly, enabling diverse applications in biological research and development.

Purpose of the Study:

To highlight the utility of phage display in selecting peptides and proteins.
To showcase its role in isolating therapeutic antibodies and engineering enzymes.

Main Methods:

Selection of peptides and proteins from libraries expressed on phage surfaces.
Application of phage display for antibody isolation and enzyme evolution.

Main Results:

Peptides have been successfully selected to bind specific receptors and antibodies.

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Semisynthetic antibodies have been developed to target various molecules.

Therapeutically relevant human antibodies are routinely isolated using phage display.

Phage display is used to analyze natural enzyme specificities and engineer new enzymes.

Conclusions:

Phage display is a versatile and crucial tool in modern biotechnology.
Its applications range from therapeutic antibody development to de novo enzyme engineering.