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Generation of Transgenic C. elegans by Biolistic Transformation
Published on: August 23, 2010
Particle bombardment: a universal approach for gene transfer to cells and tissues
T M Klein1, S Fitzpatrick-McElligott
1DuPont Agricultural Products, Experimental Station, Wilmington, Delaware 19880.
Current Opinion in Biotechnology
|October 1, 1993
Abstract:
In the past year, significant progress in the field of gene transfer has been made possible by refinement of the technique of particle bombardment. The process has been utilized for the study of gene expression in plastids and mitochondria, the production of transgenic crop plants and gene transfer into live animals. Bombarding tissues of live animals with genes that code for antigenic proteins may provide an effective means of vaccination.
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...