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Updated: Jul 22, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
Published on: May 11, 2013
Potentiometric determination of ephedrine hydrochloride using plastic membrane ion-selective electrode
M M Zareh1, Y M Issa, A F Shoukry
1Chemistry Department, Faculty of Science, Zagazig University, Egypt.
Abstract:
A plastic membrane electrode based on phenylephrine-tetraphenylborate ion association shows a Nernstian response to both ephedrinium (Ep+) and silver (Ag+) cations over the concentration ranges 2 x 10(-5)-10(-1) M and 10(-5)-10(-1) M for Ep+ and Ag+, respectively. The performance characteristics of the electrode were investigated. The electrode proved to be an excellent potentiometric sensor for the determination of Ep-hydrochloride in its pure solutions and pharmaceutical preparations using the extrapolation method and potentiometric titration using a standard solution of AgNO3.
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