Understanding flux patterns in membrane processing of protein solutions and suspensions

Membrane microfiltration is one of the most effective ways of separating proteins from materials of larger size, such as microbial cells and cell debris. Ultrafiltration is the most effective means of concentrating protein solutions. This review describes the scope and operating patterns of these processes. A major goal for membrane technologists is the development of predictive descriptions of membrane processes, based on a rigorous understanding of the underlying physico-chemical phenomena. The emphasis is placed on quantitative analysis of the interfacial aspects and microhydrodynamics of membrane processes. From existing knowledge, it is already possible to define a number of guidelines for successful filtration process operation.