Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dismantling the immune system

P Mombaerts1

  • 1Massachusetts Institute of Technology, Cambridge.

Current Opinion in Biotechnology
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Gene targeting in embryonic stem cells has rapidly produced numerous mutant mouse strains crucial for immunology research. These mouse models significantly expand experimental options for immunologists studying key immune system genes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure and emergence of specific olfactory glomeruli in the mouse.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

The human repertoire of odorant receptor genes and pseudogenes.

Annual review of genomics and human genetics·2001
Same author

Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption.

Development (Cambridge, England)·2001
Same author

Efficient metaphase II transgenesis with different transgene archetypes.

Nature biotechnology·2001
Same author

How smell develops.

Nature neuroscience·2001
Same author

Selective deletion of leptin receptor in neurons leads to obesity.

The Journal of clinical investigation·2001
Same journal

Microbial C1 assimilation pathways for chemical synthesis: from native metabolism to synthetic design.

Current opinion in biotechnology·2026
Same journal

Medicinal plants fermentation: current knowledge and perspectives.

Current opinion in biotechnology·2026
Same journal

Fermented foods: lessons learned from metagenomics.

Current opinion in biotechnology·2026
Same journal

Microfluidic platforms for the transient transfection of mammalian cells: recent developments and challenges.

Current opinion in biotechnology·2026
Same journal

Harvesting insights from recent advances in yeast genomics for predictable and precision wine fermentation.

Current opinion in biotechnology·2026
Same journal

Minimal enzyme cascades for the aromatic-to-aromatic upgrading of lignin monomers.

Current opinion in biotechnology·2026
See all related articles

Area of Science:

  • Immunology
  • Genetics
  • Developmental Biology

Background:

  • The field of immunology has seen a significant increase in the availability of genetically modified mouse models.
  • Gene targeting in embryonic stem cells is a primary method for creating these models.

Purpose of the Study:

  • To highlight the impact of newly developed mutant mouse strains on immunological research.
  • To emphasize the expanding experimental capabilities for immunologists.

Main Methods:

  • Gene targeting in embryonic stem cells to create specific mutations.
  • Development of novel gene targeting techniques.

Main Results:

  • A large number of targeted mutant mouse strains relevant to immunology have been generated.

Related Experiment Videos

  • Mutant mouse strains now exist for most critical immunology-related genes.
  • New gene targeting techniques have been successfully applied, often first in immunology.

    • Conclusions:

    • The proliferation of mutant mouse strains has revolutionized immunological research.
    • These models provide essential tools for dissecting gene function in the immune system.
    • Advancements in gene targeting technology continue to benefit immunological studies.