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Inflammatory disease: where immunology and adhesion meet?
1Department of Leukocyte Biology, Syntex Research, S3-6, Palo Alto, California 94303.
Current Opinion in Biotechnology
|December 1, 1993
Summary
Researchers are developing new drugs to control how leukocytes enter inflamed tissues. This aims to treat chronic inflammatory diseases by targeting leukocyte adhesion mechanisms.
Area of Science:
- Immunology
- Pharmacology
Background:
- Leukocyte extravasation is crucial in inflammatory responses.
- Understanding leukocyte trafficking to inflamed tissues has advanced significantly.
Purpose of the Study:
- To explore novel therapeutic agents for chronic inflammatory diseases.
- To modulate leukocyte recruitment to inflammatory sites.
Main Methods:
- Investigating mechanisms of leukocyte entry into inflamed tissues.
- Developing novel drugs targeting leukocyte adhesive interactions.
Main Results:
- Significant progress in understanding leukocyte recruitment.
- Identification of potential therapeutic targets.
Conclusions:
- Enhanced knowledge of leukocyte trafficking facilitates drug discovery.
- Novel drug classes show promise for treating chronic inflammatory diseases.