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Related Experiment Videos

Tenoxicam and renal function

R C Heintz1

  • 1Faculty of Pharmacy, University Louis Pasteur, Strasbourg, France.

Drug Safety
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Nonsteroidal anti-inflammatory drugs (NSAIDs) like tenoxicam show low renal risk in most patients. Long-term use is generally safe, but severe kidney impairment requires caution.

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Area of Science:

  • Pharmacology
  • Nephrology
  • Rheumatology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with renal adverse effects.
  • Systematic evaluation of renal risk with NSAIDs is necessary.
  • Tenoxicam is an NSAID effective for rheumatic diseases.

Purpose of the Study:

  • To determine the risk of clinically relevant renal effects in patients treated with tenoxicam.
  • To evaluate the impact of tenoxicam on renal function across diverse patient groups.

Main Methods:

  • Investigational studies up to 5 years evaluated glomerular filtration, renal blood flow, and tubular function.
  • Analysis of urinary system adverse events from clinical trials involving over 67,000 patients.
  • Inclusion of elderly patients and those with varying degrees of renal impairment.

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Main Results:

  • No clinically relevant renal toxicity was observed in patients with normal renal function, elderly patients, or those with mild to moderate renal impairment.
  • One patient with pre-existing renal pathology experienced elevated plasma creatinine after 5 years.
  • A low prevalence (0.07%) of urinary system adverse events was reported across all trials, similar in elderly and younger patients.

Conclusions:

  • Long-term treatment with tenoxicam poses a low risk of nephrotoxic effects for most patients.
  • Tenoxicam is generally safe for patients with normal or mildly to moderately impaired renal function.
  • Tenoxicam is not recommended for patients with severe pre-existing renal insufficiency.