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Related Experiment Videos

Drug-induced mania

M Peet1, S Peters

  • 1University Department of Psychiatry, Northern General Hospital, Sheffield, England.

Drug Safety
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Certain medications can trigger mania in susceptible individuals, especially those with pre-existing mood disorders. Careful review of large patient groups is essential to identify drugs causing manic symptoms.

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Area of Science:

  • Psychiatry and Pharmacology

Background:

  • Drug-induced mania is a potential adverse effect during medical treatment.
  • Patients with a predisposition to mood disorders are particularly vulnerable.
  • Reliance on single case reports is insufficient; large-scale evidence is crucial.

Purpose of the Study:

  • To identify drugs with a propensity to induce manic symptoms.
  • To differentiate between drugs with definite and probable associations with mania.
  • To review management strategies for drug-induced mania.

Main Methods:

  • Analysis of large series of treated patients.
  • Emphasis on studies including matched control groups.
  • Review of existing literature on drug-induced mania.

Main Results:

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  • Levodopa, corticosteroids, and anabolic-androgenic steroids have a definite propensity to cause mania.
  • Tricyclic antidepressants and monoamine oxidase inhibitors can induce mania in bipolar patients.
  • Other drugs like dopaminergic agents, thyroxine, and certain stimulants are probably capable of inducing mania.

Conclusions:

  • Several drug classes are associated with inducing manic symptoms.
  • Management includes drug withdrawal or dose reduction and antipsychotic or lithium treatment.
  • Further research is needed for drugs with less secure evidence of mania induction.