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Related Experiment Videos

Experimental mycoplasma mastitis in mice

J C Anderson, C J Howard, R N Gourlay

    Infection and Immunity
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    This study inoculated six mycoplasma species into mouse mammary glands, observing gland involution and neutrophil infiltration. Pathogenicity in mice generally mirrored their effects in cattle, except for Mycoplasma dispar.

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    Area of Science:

    • Veterinary Microbiology
    • Animal Pathology
    • Mycoplasma Research

    Background:

    • Mycoplasma species are significant pathogens in various animal species, including cattle.
    • Understanding the host-pathogen interactions and pathogenicity of Mycoplasma is crucial for animal health.
    • The mammary gland serves as a relevant site for studying Mycoplasma infections.

    Purpose of the Study:

    • To evaluate the pathogenicity of six different Mycoplasma species in a mouse mammary gland model.
    • To compare the pathogenic effects of these Mycoplasma species in mice with their known pathogenicity in cattle.
    • To characterize the inflammatory response within the mammary gland following Mycoplasma inoculation.

    Main Methods:

    • Inoculation of thirteen strains from six Mycoplasma species (Acholeplasma laidlawii, Mycoplasma dispar, M. bovirhinis, M. bovigenitalium, M. agalactiae subsp. bovis, M. mycoides subsp. mycoides) into the mammary glands of mice.

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  • Quantification of mycoplasma load in mammary glands three days post-inoculation.
  • Histopathological examination of inoculated mammary glands to assess inflammatory responses, specifically neutrophil infiltration and gland involution.

    • Main Results:

    • Mycoplasma inoculation induced significant pathological changes, including involution of the inoculated mammary glands.
    • A prominent neutrophil infiltration was observed in the mammary glands following inoculation, indicating an inflammatory response.
    • Five of the six Mycoplasma species exhibited pathogenicity in mice that was comparable to their known pathogenicity in cattle.

    Conclusions:

    • The mouse mammary gland model is suitable for assessing the pathogenicity of Mycoplasma species relevant to cattle.
    • Mycoplasma dispar demonstrated a different pathogenic profile in mice compared to its effects in cattle.
    • These findings contribute to understanding Mycoplasma host-pathogen interactions and have implications for veterinary disease management.