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Pressure measurements in the normal and occluded rabbit maxillary sinus
K E Scharf1, W Lawson, J M Shapiro
1Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA.
The Laryngoscope
|June 1, 1995
Summary
Maxillary sinus ostial occlusion causes negative pressure, contributing to sinusitis pathogenesis. This study quantifies sinus pressure changes in rabbits, offering insights into human maxillary sinusitis.
Area of Science:
- Otolaryngology
- Respiratory Physiology
- Medical Pathogenesis
Background:
- Maxillary sinusitis pathogenesis is linked to maxillary ostium occlusion.
- Understanding sinus pressure dynamics is crucial for sinusitis research.
Purpose of the Study:
- To investigate the effect of maxillary ostial occlusion on sinus pressure in a rabbit model.
- To quantitatively assess pressure changes in the maxillary sinus during spontaneous breathing.
Main Methods:
- Utilized anesthetized adult rabbits with a single maxillary ostium, mimicking human anatomy.
- Measured serial pressures in normal and occluded maxillary sinuses and the nasal cavity.
- Compared pressure curves during spontaneous breathing in nasal-breathing and tracheotomized rabbits.
Main Results:
- Patent ostia resulted in respiratory-synchronous pressure curves with isobaric nasal and sinus pressures.
- Occluded ostia initially led to positive pressure, followed by negative pressure reaching -28.2 ± 7.3 mm H2O.
- Negative sinus pressure developed within 20-50 minutes after ostial occlusion.
Conclusions:
- The rabbit model demonstrates that maxillary ostial occlusion induces significant negative sinus pressure.
- These findings support the role of ostial occlusion in maxillary sinusitis development.
- This quantitative study provides a foundation for further research into sinusitis pathophysiology.