Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Interpretation of numerical laboratory values]

D J Vonderschmitt1

  • 1Institut für Klinische Chemie der Universität Zürich.

Therapeutische Umschau. Revue Therapeutique
|May 1, 1995
PubMed
Summary

Interpreting laboratory test results requires considering test sensitivity, specificity, and disease prevalence. A positive test result

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensitive stereospecific determination of acenocoumarol and phenprocoumon in plasma by high-performance liquid chromatography.

Journal of chromatography. B, Biomedical sciences and applications·2000
Same author

Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn.

Clinical chemistry and laboratory medicine·1998
Same author

Development of a user-oriented completely open in vitro diagnostics system.

The Journal of automatic chemistry·1996
Same author

Characterization of interleukin-13 receptor in carcinoma cell lines and human blood cells and comparison with the interleukin-4 receptor.

Journal of receptor and signal transduction research·1995
Same author

[Cotinine--a useful biomarker for tobacco use?].

Praxis·1995
Same author

[[One needs certain experience--and quality control. Interview with Prof. D.J. Vonderschmitt. Interview by K. Reinhardt].

Therapeutische Umschau. Revue therapeutique·1995

Area of Science:

  • Clinical chemistry
  • Diagnostic accuracy
  • Medical laboratory science

Context:

  • Laboratory test results are typically classified as positive or negative using a discriminating value.
  • The reliability of a positive test result, specifically its probability of indicating the presence of a disorder, is a critical concern.

Purpose:

  • To investigate the factors influencing the reliability of positive laboratory test results.
  • To determine how test sensitivity, specificity, and disease prevalence affect the predictive value of diagnostic tests.

Summary:

  • The probability of a disorder being present given a positive laboratory test result is contingent upon the test's sensitivity, specificity, and the prevalence of the disorder in the patient population.
  • Standard reference values for laboratory tests demonstrate high specificity.
  • The predictive value of a test can be significantly enhanced by narrowing the range of potential diagnoses.

Impact:

  • Highlights the importance of considering prevalence in interpreting diagnostic test results.
  • Demonstrates that tests lacking adequate sensitivity and specificity are unsuitable for screening purposes.
  • Provides a framework for understanding and improving the diagnostic accuracy of laboratory tests.

Related Experiment Videos