[Effect of carnosine and its derivatives on ADP-induced human platelet aggregation]

ADP-induced aggregation of thrombocytes was studied in patients with cerebrovascular impairments as well as after treatment with carnosine and its native derivatives; these drugs proved to be modulators of the cell aggregation. Carnosine decreased the rate of thrombocyte aggregation in patients with high index of aggregation and exhibited the proaggregation activity in patients with low rate of aggregation. The antiaggregation activity of the preparations studied, used at physiological concentrations 3.5 mM, was increased as follows: carnosine (17%) < histidine < acetyl anserine < ophidine < anserine (35%). Application of carnosine and its native derivatives may be promising and effective in correction of thrombocyte functional properties in patients with cerebrovascular impairments.