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Metabolism of halohydroquinones in Rhodococcus chlorophenolicus PCP-1
J S Uotila1, V H Kitunen, T Coote
1Department of Applied Chemistry and Microbiology, University of Helsinki, Finland.
Biodegradation
|June 1, 1995
Abstract:
The actinomycete Rhodococcus chlorophenolicus PCP-1 metabolizes pentachlorophenol into ultimate inorganic end products via tetrachloro-p-hydroquinone. This intermediate was further dehalogenated in the cytoplasm requiring reductant in the cell free system. Tetrafluoro-p-hydroquinone and tetrabromo-p-hydroquinone were also dehalogenated. Chlorophenol analogs, thiol blocking agents and molecular oxygen inhibited the activity. The dehalogenating reactions led to 1,2,4-trihydroxybenzene, which was further metabolized into maleic acid.