[The immunomodulating action of energizing preparations under physical loading]

Area of Science:

• Exercise physiology
• Biochemistry
• Immunology

Background:

• The actoprotective effects of Riboxin are known but require enhancement.
• Mildronate's impact on physical fitness and immune response needs clarification, especially in combination with other substances.
• Understanding synergistic effects of supplements is crucial for optimizing athletic performance and recovery.

Purpose of the Study:

• To investigate the actoprotective effects of Riboxin and its potentiation by glucose and benfotiamine.
• To evaluate the impact of Mildronate on physical fitness and immune response in rats.
• To determine if combining Mildronate with glucose and benfotiamine can mitigate its negative effects and normalize immunological parameters.

Main Methods:

• Rats were subjected to swimming exercises to assess physical fitness.
• Immune response was monitored in conjunction with exercise performance.
• The effects of Riboxin, glucose, benfotiamine, and Mildronate, individually and in combination, were analyzed.

Main Results:

• Riboxin demonstrated a mild actoprotective effect, significantly enhanced by glucose and benfotiamine.
• Mildronate alone suppressed physical fitness and did not influence immune response development.
• The combination of Mildronate with glucose and benfotiamine normalized immunological responsiveness without affecting physical fitness.

Conclusions:

• Glucose and benfotiamine can enhance the actoprotective properties of Riboxin.
• Mildronate's suppressive effect on physical fitness is not overcome by combining it with glucose and benfotiamine.
• The combination therapy of Mildronate, glucose, and benfotiamine effectively normalizes immune response in stressed rats.