[The effect of antidote preparations on the immune reactions in acute dimethyl dichlorovinyl phosphate poisoning]

Experiments on CBA mice established that acute intoxication with dimethylchlorovinyl phosphate given in a single LD50 of 1.0 increased mice splenic colony-forming cells, decreased thymic T cells, delayed hypersensitivity, natural and antibody-dependent cellular cytotoxicities, sheep splenic red blood cells, thymus-independent Vi antigen antibody production. The antidote therapy with atropine (20 mg/kg) did not stop the main manifestations of posttoxication immunodeficiency and enhanced the suppression of a humoral immune response to sheep red blood cells. Dipyroxim (15 mg/kg) diminished manifestations of postintoxication immunodeficiency.