Related Experiment Video
Updated: Aug 15, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Structure determination of racemic trichogin A IV using centrosymmetric crystals
C Toniolo1, C Peggion, M Crisma
1C.N.R., Department of Organic Chemistry, University of Padova, Italy.
Abstract:
Direct methods of crystal structure solution are greatly facilitated in centrosymmetric space groups where the complexity of the phase-problem is reduced. For most peptides and proteins, crystallization in a centrosymmetric arrangement is precluded by an intrinsic dissymmetry due to the constituent chiral amino acid residues. The synthetic accessibility of peptide sequences containing amino acids of either chirality offers the possibility for co-crystallization of racemic crystals. We report here the first use of such an approach for the de novo structure determination of a medium-sized molecule, trichogin A IV, which is a constituent of a fungal lipopeptaibol mixture possessing membrane-modifying properties of biological interest.
More Related Videos
Related Concept Videos
Naming Enantiomers
Molecules with Multiple Chiral Centers
Racemic Mixtures and the Resolution of Enantiomers
Stereoisomerism of Cyclic Compounds
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Prochirality

