Comparison of conventional and ThinPrep preparations of mucoid cytology samples

Cytological specimens containing large amounts of mucus and/or blood are often a considerable problem as far as preparation and especially screening are concerned. The ThinPrep method, which uses a mucolytic and hemolysing solution and prepares slides automatically, eliminates difficulties in both areas. Comparing ThinPreps to conventionally prepared samples reveals equivalent or even superior cellular preservation. Cells are spread in a thin layer, mostly with only a minimal amount of residual mucus or blood. Screening is consequently much easier and faster. The time-saving effect does not compromise the diagnostic accuracy, as we could demonstrate with an 92% overall agreement in both procedures. The difference of 8% could possibly be attributed to inadequate splitting of the samples.