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Acquired platelet dysfunction with eosinophilia in white children
1Department of Medicine, University of Calgary, Foothills Hospital, Alberta, Canada.
Insights
Acquired platelet dysfunction with eosinophilia is rare, typically seen in Southeast Asian children. This condition was observed in two white boys after living in Malaysia, suggesting a link to regional travel.
Area of Science:
- Hematology
- Pediatrics
- Tropical Medicine
Background:
- Acquired platelet dysfunction associated with eosinophilia (APDE) is a rare bleeding disorder.
- It has primarily been documented in indigenous children from Southeast Asia and East India.
Observation:
- Two non-indigenous Caucasian boys developed APDE after residing in Malaysia for 12-18 months.
- This suggests the disorder may not be exclusive to indigenous populations.
Findings:
- The cases highlight a potential environmental or infectious trigger for APDE in travelers.
- Easy bruising and eosinophilia were key clinical indicators.
Implications:
- Clinicians should consider APDE in children presenting with bruising and eosinophilia after travel to Southeast Asia.
- Early diagnosis and management are crucial for affected children.
Abstract:
Acquired platelet dysfunction associated with eosinophilia has been described mainly in indigenous Southeast Asian and East Indian children. We describe two white boys in whom this disorder developed after they had lived in Malaysia for 12 to 18 months. Acquired platelet dysfunction associated with eosinophilia should therefore be considered in children who, after a visit to this region, have easy bruising and esoinophilia.