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[Quantitative analysis of individual renal function using 99mTc-DMSA scintigram--comparison with 131I-OIH renogram]
S Komai1, H Toyama, A Takeuchi
1Department of Radiology, Fujita Health University School of Medicine.
Kaku Igaku. the Japanese Journal of Nuclear Medicine
|April 1, 1995
Summary
99mTc-2,3-dimercaptosuccinic acid (DMSA) uptake ratio effectively quantifies individual kidney function. This method shows clinical feasibility for assessing renal reserve compared to 131I-ortho-iodo-hippuran renograms.
Area of Science:
- Nuclear Medicine
- Renal Physiology
Background:
- 99mTc-2,3-dimercaptosuccinic acid (DMSA) scintigraphy is used for renal imaging.
- Quantitative analysis of individual renal function is crucial for diagnosis and management.
Purpose of the Study:
- To evaluate the clinical feasibility of using DMSA uptake ratio for quantitative renal function analysis.
- To compare DMSA uptake ratio with 131I-ortho-iodo-hippuran (OIH) renogram patterns.
Main Methods:
- Studied 211 cases with renal disorders and 4 normal volunteers.
- Performed both DMSA and OIH renogram studies on the same day.
- Classified OIH renogram patterns into 6 types.
Main Results:
- DMSA uptake ratio showed a negative correlation with age in the normal group.
- Significantly decreased DMSA uptake ratios were observed in patients with severe impaired or non-functioning renal patterns.
- Compensatory hemi-hypertrophy kidneys had higher DMSA uptake ratios than atrophic kidneys.
Conclusions:
- DMSA uptake ratio is a feasible method for quantitative analysis of individual renal function.
- This technique can evaluate renal functional reserve and compensation.
- DMSA uptake ratio provides valuable information compared to OIH renogram patterns.