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Related Experiment Videos

Mannan-binding protein and complement dependent opsonization in alcoholic cirrhosis

C Homann1, P Garred, P Hasselqvist

  • 1Department of Medicine B, Bispebjerg Hospital, University of Copenhagen, Denmark.

Liver
|February 1, 1995
PubMed
Summary

Plasma mannan-binding protein levels are elevated in decompensated cirrhosis patients, contrary to expectations. Complement-dependent opsonization of mannan is not compromised in alcoholic cirrhosis, suggesting an acute phase response.

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Immunobiology·2020

Area of Science:

  • Immunology
  • Infectious Disease
  • Hepatology

Background:

  • Mannan-binding protein (MBP) is crucial for innate immunity, opsonizing microbes and activating complement.
  • Cirrhosis patients exhibit increased susceptibility to bacterial infections, potentially linked to impaired immune defenses.

Purpose of the Study:

  • To investigate if low MBP levels and compromised complement-dependent opsonization contribute to infection risk in cirrhosis.
  • To assess MBP concentrations and mannan opsonization in patients with compensated and decompensated alcoholic cirrhosis.

Main Methods:

  • Studied 51 compensated cirrhosis, 34 decompensated cirrhosis, and 16 healthy controls.
  • Measured plasma MBP concentrations and complement C4 deposition on yeast mannan.
  • Correlated MBP levels with clinical markers like erythrocyte sedimentation rate and fibrinogen.

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Main Results:

  • Found a significant correlation between plasma MBP and C4 deposition on mannan across all groups.
  • Unexpectedly, MBP levels and mannan opsonization were significantly increased in decompensated cirrhosis patients.
  • Elevated MBP correlated with acute phase reactants, suggesting an acute phase reaction.

Conclusions:

  • Plasma MBP levels are elevated in decompensated alcoholic cirrhosis.
  • Complement-dependent mannan opsonization is not impaired in alcoholic cirrhosis patients.
  • Increased MBP in decompensated cirrhosis may indicate an acute phase response rather than a deficiency.