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The human immunoglobulin VH repertoire
1MRC Centre for Protein Engineering, Cambridge, UK.
Immunology Today
|May 1, 1995
Summary
Researchers mapped the human immunoglobulin heavy chain variable (VH) locus on chromosome 14. This extensive 1100kb region contains 51 functional VH gene segments and numerous pseudogenes, detailing the immune system's genetic makeup.
Area of Science:
- Immunogenetics
- Genomics
- Human Molecular Biology
Background:
- The human immunoglobulin heavy chain variable (VH) locus is crucial for adaptive immunity.
- Understanding its organization is key to deciphering immune system diversity and function.
Purpose of the Study:
- To review the recently constructed complete map of the human VH locus.
- To detail the organization, polymorphism, and encoded repertoire of the VH locus.
Main Methods:
- Comprehensive mapping of the human VH locus on chromosome 14.
- Analysis of the locus's structural organization, including gene segments and pseudogenes.
Main Results:
- The human VH locus spans 1100kb on chromosome 14.
- It comprises 51 functional VH gene segments interspersed with a similar number of pseudogenes.
Conclusions:
- The complete map provides a detailed understanding of the human VH locus.
- This organization influences the diversity of the antibody repertoire and immune responses.