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Muscle GSH-Px activity after prolonged exercise, training, and selenium supplementation
1Laboratory of Biomechanics and Biology of Exercise, University of Nice, France.
Biological Trace Element Research
|January 1, 1995
Summary
Selenium supplementation did not significantly alter physiological responses to endurance training in healthy males. Muscle glutathione peroxidase showed a notable change, but overall exercise performance was unaffected by selenium.
Area of Science:
- Exercise Physiology
- Nutritional Biochemistry
Background:
- Selenium is an essential trace element involved in antioxidant defense.
- Its role in modulating physiological adaptations to exercise remains under investigation.
Purpose of the Study:
- To investigate the effects of selenium supplementation on physiological responses to acute and chronic endurance exercise.
- To examine changes in muscle and plasma parameters pre- and post-training with or without selenium.
Main Methods:
- A double-blind, placebo-controlled study involving 24 healthy males undergoing a 10-week endurance training program.
- Subjects received either 240 micrograms of organic selenium daily or a placebo.
- Physiological parameters were assessed before and after acute exercise, both pre- and post-training.
Main Results:
- Muscle glutathione peroxidase (GPx) exhibited a significant change with selenium supplementation.
- No significant differences were observed in other measured physiological parameters between the selenium and placebo groups after chronic exercise.
- Acute exercise elicited predictable physiological changes, but these were not significantly modulated by selenium.
Conclusions:
- Selenium supplementation at 240 micrograms/day did not enhance physiological adaptations to endurance training in healthy young males.
- Muscle GPx activity is responsive to selenium, but this did not translate to improved exercise performance or systemic adaptations in this cohort.