The thymic way to transplantation tolerance

Area of Science:

• Transplantation immunology
• Immunology
• Endocrinology

Background:

• Graft rejection and immunosuppressant side effects are major challenges in transplantation.
• Achieving donor-specific unresponsiveness is key to true tolerance without immunosuppression.
• The thymus is crucial for self-tolerance and acquired tolerance to foreign antigens.