Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Targeted vectors for gene therapy

N Miller1, R Vile

  • 1Laboratory of Cancer Gene Therapy, Rayne Institute, St. Thomas' Hospital, London, United Kingdom.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Surface-Topography Challenge: A Multi-Laboratory Benchmark Study to Advance the Characterization of Topography.

Tribology letters·2025
Same author

An app with brief behavioural support to promote physical activity after a cancer diagnosis (APPROACH): study protocol for a pilot randomised controlled trial.

Pilot and feasibility studies·2022
Same author

Informing patient choice and service planning in surgical voice restoration: valve usage over three years in a UK head and neck cancer unit.

The Journal of laryngology and otology·2021
Same author

Clinicopathological and prognostic significance of programmed cell death ligand 1 expression in patients diagnosed with breast cancer: meta-analysis.

The British journal of surgery·2021
Same author

MicroRNAs as biomarkers of multimodal treatment for rectal cancer.

The British journal of surgery·2021
Same author

Co-Infection with SARS-COV-2 and Parainfluenza in a young adult patient with pneumonia: Case Report.

IDCases·2020
Same journal

Sinomenine Regulates the TRIM32/IRF1/TRAF6 Axis to Inhibit Pyroptosis in Atopic Dermatitis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Urolithin A Mitigates Renal Fibrosis by Promoting Fatty Acid Oxidation Through Orchestrating β-Catenin Signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

MiR-124 Inhibits Lipid Deposition in Mouse Liver by Targeting the Trib3/Hnf4α Pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

TCN2 Drives Psoriasis-Like Inflammation and Keratinocyte Hyperproliferation, Correlating With IL-1β and STAT3 Activation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

The Synthetic Melanocortin Agonist NDP-MSH Ameliorates THSD7A-Associated Membranous Nephropathy in an Active Immunization Mouse Model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Brain-Derived Neurotrophic Factor and Associated Signaling in Kidney Diseases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
See all related articles

Improving gene therapy delivery involves enhancing targeting accuracy and efficiency. This review explores current methods and future strategies for precise gene delivery to target cells, minimizing off-target effects.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genetics

Background:

  • Gene therapy necessitates effective delivery of therapeutic genes to target cells.
  • Current delivery systems face challenges in accuracy, efficiency, and specificity.
  • Off-target transduction can lead to detrimental effects in normal cells.

Purpose of the Study:

  • To review methods for improving the targeting of gene therapy delivery systems.
  • To discuss the manipulation of plasmid and viral vectors for enhanced specificity.
  • To explore emerging vectors and future composite delivery systems.

Main Methods:

  • Engineering surface components of viral and liposomal vectors for target cell recognition.
  • Incorporating transcriptional elements into vector genomes for cell-specific expression.

Related Experiment Videos

  • Reviewing current literature on gene therapy delivery systems.

    • Main Results:

    • Surface component engineering improves target cell discrimination.
    • Transcriptional targeting restricts therapeutic gene expression to desired cell types.
    • Composite vectors offer potential for improved future gene delivery.

    Conclusions:

    • Current gene therapy delivery systems can be manipulated for better targeting.
    • Future delivery systems will likely integrate features from diverse vector types.
    • Enhanced targeting is crucial for safe and effective gene therapy outcomes.