Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does iron deficiency raise the seizure threshold?

N L Kobrinsky1, J Y Yager, M S Cheang

  • 1Department of Pediatrics, University of North Dakota, Fargo.

Journal of Child Neurology
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain biocompatibility and microglia response towards engineered self-assembling (RADA)4 nanoscaffolds.

Acta biomaterialia·2016
Same author

Broccoli sprout supplementation during pregnancy prevents brain injury in the newborn rat following placental insufficiency.

Behavioural brain research·2015
Same author

Hepatotoxicity in acute iron poisoning.

Human & experimental toxicology·2005
Same author

Long term effects of a home visit to prevent childhood injury: three year follow up of a randomized trial.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2005
Same author

Combined immunosuppression with cyclosporine, rapamycin, and mycophenolate mofetil controls rejection with minimal nutritional impact in experimental small intestinal transplantation.

Transplantation proceedings·2002
Same author

Hepatotoxicity in acute iron poisoning.

Journal of toxicology. Clinical toxicology·2002

Iron deficiency may protect against febrile seizures in children. Children with febrile seizures showed better iron status compared to those without, suggesting a potential protective effect of iron deficiency.

Area of Science:

  • Pediatric Neurology
  • Hematology
  • Biochemistry

Background:

  • Febrile seizures are common in children.
  • Iron deficiency is a prevalent nutritional deficiency in pediatric populations.
  • The relationship between iron status and seizure threshold is not fully understood.

Purpose of the Study:

  • To investigate the association between iron status and the occurrence of febrile seizures in children.
  • To determine if iron deficiency influences the seizure threshold in pediatric patients.

Main Methods:

  • Prospective evaluation of iron sufficiency measures in 51 children presenting with febrile illness.
  • Comparison of iron status indicators (free erythrocyte protoporphyrin, hemoglobin, hematocrit, MCV, MCH, platelet count) between children with and without febrile seizures.

Related Experiment Videos

  • Adjustment for confounding factors including family history.

    • Main Results:

    • Children with febrile seizures were significantly less likely to be iron deficient based on multiple biochemical markers.
    • Lower prevalence of iron deficiency was observed in the febrile seizure group compared to controls (P < .01 for free erythrocyte protoporphyrin).
    • This association remained significant after adjusting for family history.

    Conclusions:

    • Iron deficiency may have a protective effect against the development of febrile seizures in children.
    • Further research is warranted to elucidate the mechanisms underlying this potential protective association.
    • Clinical implications for iron supplementation strategies in at-risk populations should be considered.