Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphological changes in indefinitely surviving enhanced ectopic rat cardiac allografts

N L Tilney, P R Bell, R N MacSween

    The Journal of Pathology
    |May 1, 1976
    PubMed
    Summary

    Histological analysis of rat cardiac allografts revealed chronic inflammation and fibrosis in the heart muscle. Coronary arteries showed intimal hyperplasia and internal elastic lamina disruption, indicating significant graft changes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A semi-centennial report on the participants depicted in Joel Babb's portrait, 'the first successful kidney transplantation'.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007
    Same author

    The commercialization of transplantation.

    Transplantation proceedings·2003
    Same author

    Improvements in early behaviour of kidney allografts after donor treatment.

    Transplantation proceedings·2002
    Same author

    Activation of proinflammatory mediators in heart transplants from brain-dead donors: evidence from a model of chronic rat cardiac allograft rejection.

    Transplantation proceedings·2002
    Same author

    Improvements in early behavior of rat kidney allografts after treatment of the brain-dead donor.

    Annals of surgery·2001
    Same author

    Molecular and cellular events associated with ischemia/reperfusion injury.

    Annals of transplantation·2001

    Area of Science:

    • Cardiovascular pathology
    • Transplantation immunology
    • Histopathology

    Background:

    • Ectopic cardiac allografts are crucial models for studying transplant rejection.
    • Understanding the histological hallmarks of rejection is vital for improving graft survival.

    Purpose of the Study:

    • To characterize the specific histological alterations occurring in ectopic cardiac allografts in a rat model.
    • To identify key pathological features indicative of graft damage and rejection.

    Main Methods:

    • Histological examination of ectopic cardiac allografts.
    • Microscopic analysis of myocardial and coronary artery tissues.
    • Assessment of inflammatory cell infiltration, fibrosis, and intimal hyperplasia.

    Related Experiment Videos

    Main Results:

    • Diffuse chronic inflammatory cell infiltrate observed in the myocardial interstitium.
    • Variable degrees of interstitial fibrosis were present alongside inflammation.
    • Coronary arteries exhibited intimal hyperplasia and disruption of the internal elastic lamina.

    Conclusions:

    • Ectopic cardiac allografts in rats undergo significant histological changes consistent with chronic rejection.
    • These changes include myocardial inflammation, fibrosis, and vascular pathology (intimal hyperplasia).
    • The findings highlight the utility of this model for investigating transplant rejection mechanisms.