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[The clinico-hemodynamic effects of the antioxidant ceruloplasmin in IHD patients]
Terapevticheskii Arkhiv
|January 1, 1995
Insights
Ceruloplasmin treatment improved exercise tolerance and quality of life in coronary heart disease (CHD) patients. This therapy also helped slow disease progression and positively impacted heart function.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Coronary heart disease (CHD) poses significant challenges in patient management.
- Limited therapeutic options exist to improve exercise tolerance and slow disease progression in CHD.
Purpose of the Study:
- To investigate the effects of ceruloplasmin on patients with coronary heart disease.
- To assess ceruloplasmin's impact on angina severity, hemodynamics, and exercise capacity.
Main Methods:
- A study comparing ceruloplasmin treatment with placebo in CHD patients.
- Evaluation of angina pectoris severity, central hemodynamics, and exercise tolerance.
Main Results:
- Ceruloplasmin administration led to increased exercise tolerance.
- Patients receiving ceruloplasmin reported a higher quality of life.
- Ceruloplasmin treatment demonstrated an arrest in disease progression.
- Combined therapy including ceruloplasmin positively affected central hemodynamics and myocardial function.
Conclusions:
- Ceruloplasmin shows promise as a therapeutic agent for coronary heart disease.
- Treatment with ceruloplasmin improves key clinical outcomes in CHD patients.
- Ceruloplasmin enhances cardiovascular function and patient well-being in CHD.
Abstract:
Ceruloplasmin- and placebo-treated CHD patients were studied for severity of angina pectoris, changes in central hemodynamics, exercise tolerance. It is shown that ceruloplasmin promoted an increase in exercise tolerance, higher quality of life, arrest of the disease progress. Combined treatment of CHD incorporating ceruloplasmin produced a positive effect on central hemodynamics and contractile, pump capacities of the myocardium.