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Updated: Aug 12, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Brain infarction developed in hypertensive and normotensive patients during hospitalization--hemodynamic factors

H Sugimori1, S Ibayashi, K Fujii

  • 1Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Angiology
|June 1, 1995
PubMed

Insights

Lowering blood pressure (BP) too much may trigger ischemic stroke in hypertensive or stroke patients. This can lead to new or recurring brain infarction events.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Clinical Research

Background:

  • Ischemic stroke is a leading cause of disability and mortality.
  • Understanding the role of blood pressure fluctuations is crucial for stroke prevention.
  • Vascular risk factors significantly influence stroke development.

Purpose of the Study:

  • To investigate the relationship between blood pressure changes and ischemic stroke onset.
  • To analyze the impact of hypertension and previous stroke history on blood pressure dynamics before stroke.

Main Methods:

  • Retrospective analysis of 17 acute brain infarction patients during hospitalization.
  • Monitoring of mean arterial blood pressure (MABP) relative to stroke onset.
  • Comparison of BP trends in hypertensive (HT) versus normotensive (NT) patients.
  • Assessment of BP changes in patients with and without a history of stroke.

Main Results:

  • Hypertensive patients had higher admission MABP (137 mmHg) than normotensives (101 mmHg).
  • Antihypertensive treatment led to a significant MABP decrease (22 mmHg) before stroke in HT patients.
  • MABP remained relatively stable in normotensive patients before stroke.
  • Patients with previous stroke history showed a notable MABP reduction (17 mmHg) prior to the event.

Conclusions:

  • Excessive blood pressure reduction may precipitate ischemic stroke in hypertensive or recurrent stroke patients.
  • Blood pressure management requires careful consideration in patients with vascular risk factors.
  • Further research is needed to establish optimal BP targets for stroke prevention.

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