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Effect of methacholine on mucociliary transport in bovine trachea in vitro
M H Mars1, P A Henricks, R Hajer
1Department of Large Animal Medicine and Nutrition, Veterinary Faculty, Utrecht, The Netherlands.
American Journal of Veterinary Research
|April 1, 1995
Abstract:
A method is described to evaluate pharmacologic influence on bovine tracheal mucus transport in vitro. In this model, cholinergic agonist methacholine stimulated transport velocity. Methacholine at concentration of 10(-6)M increased velocity by 13.6%, whereas 10(-5)M increased velocity by 26%. Stimulation was inhibited by atropine.