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Antiallergic dimeric prenylbenzoquinones from Ehretia microphylla
S Yamamura1, L R Simpol, K Ozawa
1Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
Phytochemistry
|May 1, 1995
Abstract:
The ethyl acetate-soluble portion of the MeOH extract of Ehretia microphylla showed inhibitory activity on exocytosis in antigen-stimulated rat basophils. The bioassay-guided separation of this fraction afforded five biologically active compounds. By means of chemical and spectroscopic methods, the structures of these compounds, which include microphyllone, a unique dimeric prenylbenzoquinone, and its congeners, were elucidated.