Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tuberculous lymphadenitis: extended cytomorphologic features

A A Pandit1, P H Khilnani, A S Prayag

  • 1Department of Pathology, Seth Gordhandas Sunderdas Medical College, Parel, Bombay, India.

Diagnostic Cytopathology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metastatic choriocarcinoma: an unusual cause of severe anaemia.

Journal of postgraduate medicine·2005
Same author

Gonadoblastoma with distinctly unusual pattern of yolk sac tumour overgrowth.

Journal of postgraduate medicine·2003
Same author

Worrisome histologic alterations following fine needle aspiration of the thyroid.

Acta cytologica·2001
Same author

Infarction of a thyroid nodule after fine needle aspiration biopsy.

Acta cytologica·1998
Same author

Cutaneous blastomycosis. Report of a case with diagnosis by fine needle aspiration cytology.

Acta cytologica·1997
Same author

Adult filarial worm in a fine needle aspirate of a soft tissue swelling.

Acta cytologica·1997
Same journal

Pleural Fluid Cytology Detects Small Cell Carcinoma Transformation in EGFR-Mutant Lung Adenocarcinoma: A Case Report.

Diagnostic cytopathology·2026
Same journal

Clinical and Cytopathological Significance of Intracytoplasmic Lumina and Immunohistochemical Mucin Expression in Non-Muscle-Invasive Urothelial Carcinoma of the Bladder.

Diagnostic cytopathology·2026
Same journal

Pleural Effusion Cytology of Metastatic Sclerosing Epithelioid Fibrosarcoma.

Diagnostic cytopathology·2026
Same journal

Turnaround Time Trends in Cervical Cytology Screening in South Africa, 2005-2023.

Diagnostic cytopathology·2026
Same journal

Spontaneous Infarction of Benign Salivary Gland Tumors: A Series of 5 Cases.

Diagnostic cytopathology·2026
Same journal

Atypical Carcinoid Tumor Metastatic to the Parotid Gland: A Case Report and Review of the Literature.

Diagnostic cytopathology·2026
See all related articles

Eosinophilic structures (ES) in fine-needle aspiration cytology (FNAC) can aid tuberculosis diagnosis when granulomas are absent. These structures are identified as degenerated granulomas, offering an extended diagnostic criterion for tuberculous lymphadenitis.

Area of Science:

  • Pathology
  • Cytology
  • Infectious Diseases

Background:

  • Tuberculous lymphadenitis diagnosis can be challenging with fine-needle aspiration cytology (FNAC) when only caseous necrosis is present without epithelioid cell granulomas.
  • Acid-fast bacilli (AFB) staining may be negative in such cases, posing a diagnostic dilemma.

Purpose of the Study:

  • To investigate the nature of eosinophilic structures (ES) observed in FNAC smears.
  • To determine the diagnostic role of ES in tuberculosis.

Main Methods:

  • Analysis of seventy FNAC smears from confirmed tuberculous lymphadenitis cases.
  • Classification of smears based on cytomorphological features, noting the association of ES with other criteria.
  • Immunoperoxidase staining to assess ES reactivity to tuberculous antigen and compare positivity intensity with granuloma types.

Related Experiment Videos

Main Results:

  • Eosinophilic structures (ES) were identified as pink, homogenous structures with irregular shapes and defined margins.
  • ES were found to be degenerated granulomas.
  • Immunoperoxidase staining confirmed the reactivity of ES to tuberculous antigen.

Conclusions:

  • Eosinophilic structures (ES) represent degenerated granulomas.
  • ES serve as an extended diagnostic criterion for tuberculous lymphadenitis, particularly when granulomas are not clearly identifiable.