Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The new human genetics

R P Erickson1, S E Lewis

  • 1Angel Charity for Children-Wings for Genetic Research, Steele Memorial Children's Research Center, Department of Pediatrics, University of Arizona, Tucson, USA.

Environmental and Molecular Mutagenesis
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manual Lymph Drainage for Alzheimer's Dementia: A Clinical Trial Whose Time Has Come?

Lymphology·2025
Same author

Format Correction: The Re-Discovery of Dural (Meningeal) Lymphatics: Amnesia or Ambition?

Lymphology·2025
Same author

Updated Human Chromosome Map of Lymphedema-lymphangiogenesis Genes: Template for Current and Future Discovery.

Lymphology·2025
Same author

Brain Lymphatics: Rediscovery and New Insights into Lymphatic Involvement in Diseases of Human Brains.

Lymphology·2024
Same author

The Re-Discovery of Dural (Meningeal) Lymphatics: Amnesia or Ambition?

Lymphology·2024
Same author

Centrifugal Versus Centripetal Origin(s) of the Lymphatic System: Controversy (Mostly) Resolved?

Lymphology·2023
Same journal

Resveratrol Mitigates Haloacetaldehyde Disinfection By-Products (HAL-DBPs)-Induced Oocyte Developmental Toxicity via Mitochondria-Dependent Pathways.

Environmental and molecular mutagenesis·2026
Same journal

DZNep: A Methyltransferase Modulator for Disease Mitigation.

Environmental and molecular mutagenesis·2026
Same journal

Transcriptional Dysregulation of Histone Methyltransferase Genes and Chromosomal Instability Associated With Chronic Pesticide Exposure.

Environmental and molecular mutagenesis·2026
Same journal

Evaluation of Type 1 Error Rates in Duplex Sequencing for Mutagenicity Testing Using Vehicle Control Data and Simulation Analyses.

Environmental and molecular mutagenesis·2026
Same journal

Benzo[b]fluoranthene Induces Mutation Accumulation and Cancer-Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood.

Environmental and molecular mutagenesis·2026
Same journal

Multi-Omics Integration Into Adverse Outcome Pathway Framework: Principles, Progress, and Prospects for Next-Generation Toxicological Risk Assessment.

Environmental and molecular mutagenesis·2026
See all related articles

Recent advances in human genetics reveal new insights into mutagenesis. Key findings include trinucleotide repeat expansion causing inherited diseases and active transposons in humans.

Area of Science:

  • Genetics
  • Molecular Biology
  • Human Health

Background:

  • Human genetics research is crucial for understanding mutagenesis.
  • Advances in molecular biology offer new perspectives on genetic diseases.
  • Environmental factors and genetic mutations contribute to disease.

Purpose of the Study:

  • To survey recent advances in human genetics relevant to mutagenesis.
  • To highlight key findings in genetic disease mechanisms.
  • To provide an overview for a special issue on environmental and molecular mutagenesis.

Main Methods:

  • Literature review of recent advances in human genetics.
  • Analysis of evidence for trinucleotide repeat expansion.
  • Discussion of transposon activity in humans.

Related Experiment Videos

  • Case examples of single-gene mutations causing diverse diseases.
  • Review of mitochondrial mutations and genomic imprinting.

    • Main Results:

    • Trinucleotide repeat expansion is a mechanism for anticipation in inherited diseases.
    • Transposable elements are active in the human genome.
    • Single genes can harbor mutations leading to distinct diseases.
    • Mitochondrial DNA mutations and genomic imprinting play roles in disease.
    • Epigenetic inheritance via protein-protein interactions is relevant.

    Conclusions:

    • Human genetics offers critical insights into mutagenesis.
    • Multiple genetic mechanisms contribute to inherited diseases.
    • Further research into these areas is essential for understanding and treating genetic disorders.