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Polycystic kidney disease and infertility
E F van der Linden1, A K Bartelink, B W Ike
1Department of Urology, Eemland Hospital, Amersfoort, The Netherlands.
Fertility and Sterility
|July 1, 1995
Summary
Polycystic kidney disease can cause male infertility due to obstructive azoospermia. Cysts in the seminal vesicles compressed the reproductive tract, preventing sperm passage despite normal sperm production.
Area of Science:
- Nephrology
- Andrology
- Reproductive Medicine
Background:
- Polycystic kidney disease (PKD) is a genetic disorder.
- Infertility is a potential complication in men with PKD.
- The exact mechanisms of infertility in PKD are not fully understood.
Observation:
- A 32-year-old man with adult PKD presented with infertility and testicular pain.
- Physical examination showed severe bilateral epididymal congestion.
- Semen analysis revealed azoospermia and low fructose levels.
Findings:
- Testicular biopsy confirmed normal spermatogenesis.
- Imaging demonstrated severe congestion and cystic changes in the seminal vesicles.
- These seminal vesicle abnormalities were linked to obstructive azoospermia.
Implications:
- Seminal vesicle cysts can cause male infertility through ductal compression.
- This case highlights the importance of evaluating seminal vesicles in infertile men with PKD.
- Understanding these mechanisms can guide fertility treatments for affected individuals.