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Related Experiment Videos

Vancomycin

B A Cunha1

  • 1Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, USA.

The Medical Clinics of North America
|July 1, 1995
PubMed
Summary

Vancomycin, an antibiotic for serious gram-positive infections, should not be used empirically to prevent VRE. Monitoring vancomycin serum levels is unnecessary as the drug is not nephrotoxic.

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Postgraduate medicine·2016

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Nephrology

Background:

  • Vancomycin is a critical glycopeptide antibiotic for severe gram-positive infections.
  • It is also used for Clostridioides difficile infections and endocarditis prophylaxis.

Purpose of the Study:

  • To evaluate the current guidelines and necessity of vancomycin usage.
  • To assess the cost-effectiveness and clinical utility of monitoring vancomycin serum levels.

Main Methods:

  • Review of current clinical practices and literature regarding vancomycin.
  • Analysis of nephrotoxicity data and emergence of vancomycin-resistant enterococci (VRE).

Main Results:

  • Vancomycin is generally safe and not nephrotoxic in most patients.
  • Empiric use and routine serum level monitoring of vancomycin are not cost-effective and may promote VRE.

Conclusions:

  • Vancomycin should be reserved for specific indications and not used empirically.
  • Discontinuation of routine vancomycin serum level monitoring is recommended to reduce costs and prevent resistance.

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