The pharmacotherapy of spinal spasticity: a decade of progress. II. Therapeutics

Spinal spasticity is the term used to describe the increase in muscle tone which often develops following spinal cord injury (SCI). A review of spasticity and approaches to its treatment has been presented in a previous article. The purpose of this paper is to discuss the pharmacologic agents that are currently used to treat spinal spasticity. These medications can be classified as centrally and peripherally acting agents. The following review is therefore organized into two sections, according to the site of drug action.