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Recurrence of pemphigus vulgaris associated with interleukin 2 therapy
R Prussick1, R T Plott, J R Stanley
1Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.
Archives of Dermatology
|July 1, 1994
Abstract
Background:
Immunotherapy with recombinant interleukin 2 may result in regression of metastatic cancer, particularly malignant melanoma and renal cell carcinoma.
Observations:
We describe a patient who received interleukin 2 immunotherapy for metastatic renal cell carcinoma. After his second course of treatment, he developed a recurrence of pemphigus vulgaris that had been in remission for 10 years.
Conclusions:
Interleukin 2 therapy may be associated with recurrence of an autoimmune disease, perhaps because of its ability to stimulate autoantibody production.