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[Is there a relationship between cholelithiasis and colorectal cancer?]
1Servicio Cirugia General y del Aparato Digestivo III., Hospital Clínic, Barcelona.
Problem:
The pathogenesis of colorectal cancer must be perceived as a complex interaction between the genetic make-up of the individual and the environment. Recent publications stress the association between colorectal carcinoma and cholelithiasis.
Objective:
A retrospective study was set up to compare the presence of cholelithiasis/cholecystectomy in patients with colorectal carcinoma vs gastric carcinoma.
Patients:
In 481 patients with colorectal carcinoma, and in another group of 126 patients with gastric carcinoma, the incidence of prior cholelithiasis/cholecystectomy was investigated.
Results:
In the colorectal carcinoma cases a personal history the cholelithiasis was observed more often than cholecystectomy, 88 vs 8 (P < 0.001) patients, and cholelithiasis was more commonly observed in cases of right-sided colonic cancer, than in cancer of the left colon and rectum. In the group with gastric carcinoma the cholelithiasis incidence was 5.6 percent.
Conclusions:
These findings suggest that a relationship was found more often between colorectal cancer and cholelithiasis, that with cholecystectomy.