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Characterization of an antithrombotic peptide from kappa-casein in newborn plasma after milk ingestion
B Chabance1, P Jollès, C Izquierdo
1CNRS URA 1188, Laboratoire des Protéines, Université de Paris V, France.
Insights
Bioactive peptides from milk, bovine and human kappa-caseinoglycopeptides, were found in newborn infant plasma. These antithrombotic peptides are released during digestion of formula or human milk.
Area of Science:
- Biochemistry
- Pediatrics
- Nutrition
Background:
- Kappa-casein is a major milk protein.
- Kappa-caseinoglycopeptides are derived from kappa-casein.
- These peptides possess antithrombotic properties.
Purpose of the Study:
- To detect bovine and human kappa-caseinoglycopeptides in newborn infant plasma.
- To investigate the origin of these peptides in infants.
Main Methods:
- Analysis of plasma samples from 5-day-old infants.
- Detection of bovine kappa-caseinoglycopeptides after formula feeding.
- Detection of human kappa-caseinoglycopeptides after human milk feeding.
Main Results:
- Physiologically active concentrations of bovine kappa-caseinoglycopeptides were detected in infant plasma after formula ingestion.
- Physiologically active concentrations of human kappa-caseinoglycopeptides were detected in infant plasma after human milk ingestion.
- These findings suggest the peptides are released during digestion.
Conclusions:
- Bovine and human kappa-caseinoglycopeptides are absorbed by newborn infants.
- These bioactive peptides are present in infant circulation after milk consumption.
- Digestion of milk proteins releases these antithrombotic peptides.
Abstract:
Bovine and human kappa-caseinoglycopeptides, two antithrombotic peptides derived from the corresponding kappa-caseins, were detected in physiologically active concentrations in the plasma of 5-d-old newborn infants after ingestion of cow's-milk-based formula or human milk respectively. It is suggested that these two bioactive peptides are released from milk proteins during digestion.