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Related Experiment Videos

Can haloperidol disguise fever?

S Vybíral1, R Veselá

  • 1Department of Physiology and Development Biology, Faculty of Science, Charles University, Prague, Czech Republic.

Physiological Research
|January 1, 1994
PubMed
Summary

Haloperidol induces hypothermia in rabbits by lowering the body temperature threshold for cold responses. This effect is most pronounced during early fever stages.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Physiology

Background:

  • Fever involves complex thermoregulatory adjustments.
  • Haloperidol is a dopamine antagonist with known effects on thermoregulation.

Purpose of the Study:

  • To investigate the hypothermic effect of haloperidol in cold-exposed febrile rabbits.
  • To determine the mechanism underlying haloperidol-induced hypothermia.

Main Methods:

  • Intraperitoneal administration of haloperidol to rabbits exposed to cold and induced fever.
  • Monitoring of central body temperature, cold thermogenesis, and vasomotion thresholds.

Main Results:

  • Haloperidol induced a significant hypothermic effect.
  • The hypothermia resulted from a downward shift in the threshold for cold thermogenesis and vasomotion.
  • This shift was more prominent in the early phase of fever compared to the late phase.
  • High doses of haloperidol abolished fever-induced hyperthermia.

Conclusions:

  • Haloperidol effectively reduces body temperature in febrile states by altering thermoregulatory set points.
  • The drug's impact on thermoregulation is phase-dependent during fever.

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