Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

QT dispersion in essential hypertension

P B Clarkson1, A A Naas, A McMahon

  • 1University Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK.

QJM : Monthly Journal of the Association of Physicians
|May 1, 1995
PubMed
Summary

Increased QT dispersion, a measure from ECGs, is linked to sudden cardiac death risk in hypertensive patients. This finding holds true even without electrocardiographic left ventricular hypertrophy, suggesting a simple screening tool.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

USPIO enhanced MR imaging in CNS tumors (UMIC): a study protocol.

Nanomedicine (London, England)·2026
Same author

Dyrk1a inhibition with the Novel Compound DYR533: A Cross-Disease Therapeutic Strategy Targeting Amyloidosis, Tau Pathogenesis, and Neuroinflammation.

bioRxiv : the preprint server for biology·2026
Same author

Commonly encountered central nervous system infections in the intensive care unit.

BJA education·2023
Same author

A review of approaches to <sup>18</sup> F radiolabelling affinity peptides and proteins.

Journal of labelled compounds & radiopharmaceuticals·2018
Same author

Determination of Total Biotin by Liquid Chromatography Coupled with Immunoaffinity Column Cleanup Extraction: Multilaboratory Testing, Final Action 2016.02.

Journal of AOAC International·2017
Same author

Development of a method for the preparation of zirconium-89 radiolabelled chitosan nanoparticles as an application for leukocyte trafficking with positron emission tomography.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2017

Area of Science:

  • Cardiology
  • Clinical Electrophysiology

Background:

  • Increased QT dispersion is a known risk factor for sudden cardiac death (SCD) in various cardiovascular conditions.
  • Hypertension, especially with left ventricular hypertrophy (LVH), elevates SCD risk.

Purpose of the Study:

  • To investigate the correlation between QT dispersion and echocardiographic left ventricular hypertrophy (echo LVH) in untreated essential hypertensive patients.
  • To assess if QT dispersion can serve as a non-invasive marker for identifying hypertensive individuals at high risk of SCD.

Main Methods:

  • Sixty-nine untreated essential hypertensive patients underwent ECG for QT dispersion measurement and echocardiography for LVH assessment.
  • Office and 24-hour ambulatory blood pressure monitoring were performed.
  • Multivariate analysis was used to determine relationships between QT dispersion and clinical parameters.

Related Experiment Videos

Main Results:

  • Significant relationships were found between QT dispersion and office systolic blood pressure, and left ventricular mass index.
  • These correlations persisted even after correcting for heart rate (QTc dispersion).
  • The association between QT dispersion and hypertension risk factors remained significant even when excluding patients with electrocardiographic LVH.

Conclusions:

  • Increased QT dispersion is present in essential hypertensive patients at higher risk of sudden death.
  • QT dispersion measurement offers a simple, non-invasive method for screening high-risk hypertensive patients, independent of electrocardiographic LVH.