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Related Experiment Videos

Bacteraemia in patients presenting with fever

P L Petit1, J V Haarlem, M Poelman

  • 1Department of Microbiology, University Hospital Leiden, The Netherlands.

East African Medical Journal
|February 1, 1995
PubMed
Summary

Empirical antibiotic use is common in African patients with fever, but bacterial infections are infrequent. Diagnostic cultures and sensitivity testing are crucial for targeted treatment of bacterial infections.

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Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Tropical Medicine

Background:

  • Fever is a common presenting symptom in patients admitted to hospitals in Ghana and Kenya.
  • Antimalarial and antibiotic treatments are frequently administered, often empirically.

Purpose of the Study:

  • To evaluate the prevalence of bacterial infections and antibiotic resistance in febrile patients in Ghana and Kenya.
  • To assess the appropriateness of current treatment protocols for fever in these regions.

Main Methods:

  • Blood cultures were performed on 639 patients admitted with fever.
  • Organisms were identified, and antibiotic susceptibility testing was conducted.
  • Patient diagnoses and treatments were reviewed.

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Main Results:

  • Bacteraemia was present in 11.3% of patients overall, and 23% of HIV-positive patients.
  • Commonly isolated bacteria included Salmonella, Klebsiella/Enterobacter, and S. aureus.
  • High rates of antibiotic resistance were observed, with significant resistance to amoxycillin, cotrimoxazole, and chloramphenicol.

Conclusions:

  • Empirical antibiotic use in febrile patients in Ghana and Kenya is often unwarranted.
  • Diagnostic cultures and sensitivity testing are essential for guiding appropriate treatment.
  • Targeted antimicrobial therapy based on confirmed diagnoses can improve outcomes and combat resistance.