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[A case of pseudoxanthoma elasticum underwent coronary artery bypass grafting]
Y Iguro1, Y Morishita, S Shimokawa
1Second Department of Surgery, Kagoshima University of Medicine, Japan.
Insights
This report details a rare case of pseudoxanthoma elasticum (PXE) successfully treated with coronary artery bypass grafting (CABG). The patient experienced an uneventful recovery, highlighting CABG as a viable option for PXE patients with coronary artery disease.
Area of Science:
- Cardiovascular Medicine
- Genetics and Rare Diseases
Background:
- Pseudoxanthoma elasticum (PXE) is a rare genetic disorder affecting elastic tissues.
- PXE can manifest with cardiovascular complications, including coronary artery disease.
Observation:
- A 41-year-old woman with PXE presented with significant three-vessel coronary artery lesions.
- Coronary angiography confirmed the extent of the disease.
- The left internal mammary artery was unsuitable for grafting due to obstruction.
Findings:
- Coronary artery bypass grafting (CABG) was successfully performed using saphenous vein grafts.
- The patient's postoperative course was uneventful for three years.
- Histological examination of the ascending aorta confirmed PXE-related changes.
Implications:
- This case underscores the importance of considering cardiovascular involvement in PXE patients.
- Successful CABG in PXE patients, though rare, offers a potential treatment pathway.
- This is the third reported case of PXE undergoing CABG in Japan, contributing to limited existing literature.
Abstract:
A case of pseudoxanthoma elasticum (PXE) underwent coronary artery grafting is reported. Coronary angiography of a woman with age of 41 with PXE revealed three vessels lesions. Coronary artery bypass grafting using saphenous vein grafts was performed. The left internal mammary artery was not able to use because of obstruction. Her postoperative course is uneventful for 3 years to date. Histological examination of a segment of ascending aorta revealed changes of PXE underwent CABG is extremely rare. This is the third reported case in Japan.